اثر بازدارندگی گیاه دارویی عدس الملک (Securigera securidaca) بر بروز فشار خون ریوی در جوجه‌های گوشتی پرورشی در مناطق مرتفع

نوع مقاله: مقاله کامل

نویسنده

استادیار، گروه علوم دامی،دانشکده ی کشاورزی، دانشگاه شهرکرد، شهرکرد - ایران

چکیده

این آزمایش به منظور بررسی تاثیر استفاده از پودر دانه گیاه دارویی عدس‌الملک بر عملکرد لاشه، فراسنجه‌های سرمی و خونی، سیستم ایمنی و بیان ژن‌های سوپر اکسید دیسموتاز 1، نیتریک اکسید سنتتاز و اندوتلین-1 در بطن راست قلب جوجه‌های گوشتی پرورش‌یافته در ارتفاع 2150 متری از سطح دریا انجام گرفت. آزمایش در قالب طرح کاملا ً تصادفی با پنج تیمار و چهار تکرار به مدت 42 روز انجام گردید. تیمارهای آزمایشی شامل تیمار کنترل که فاقد دانه عدس‌الملک و تیمارهای دو، سه، چهار و پنج که به ترتیب حاوی یک، دو، سه و چهار گرم در کیلوگرم جیره از این دانه بودند. نتایج نشان داد که افزودن پودر دانه عدس‌الملک به خوراک، بازده لاشه و ران را افزایش معنی‌دار و بازده قلب و نسبت بطن راست به کل بطن‌ها را کاهش معنی‌داری داده‌است (05/0 > p). همچنین در تیمارهای حاوی سه و چهار گرم دانه عدس الملک، میزان پروتئین و اکسید نیتریک سرم افزایش معنی دار و مالون دی الدئید، اسید اوریک و نسبت هتروفیل به لنفوسیت کاهش معنی‌داری نسبت به گروه کنترل دارد (05/0 > p). همچنین سطوح سه و چهار گرم عدس‌الملک موجب افزایش معنی‌دار بیان ژن‌های‌ نیتریک اکسید سنتتاز و سوپر اکسید دیسموتاز 1 و کاهش معنی‌دار بیان ژن اندوتلین-1 در بطن راست قلب گردید (05/0 > p). نتیجه‌گیری می‌شود گیاه دارویی عدس‌الملک با بهبود شرایط آنتی‌اکسیدانی، ایمنی و فراسنجه‌های بیوشیمیایی خون بر کاهش فشار خون ریوی در جوجه‌های گوشتی موثر می‌باشد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

The inhibition of Securigera securidaca herb on the incidence of pulmonary hypertension in broiler chickens reared at high altitude

نویسنده [English]

  • B. Ahmadipour gounaghani
Assistant Professor, Department of Animal Science, Faculty of Agriculture, Shahrekord University, Shahrekord, Iran.
چکیده [English]

This experiment was conducted to investigate the effects of different levels of Securigera securidaca seed powder on carcass performance, blood and serum parameters, immune system and the expression of superoxide dismutase, nitric oxide synthase and endothelin-1 genes in the right ventricle of broiler chicks grown at a height of 2150 m above sea level. The experiment was conducted in a completely randomized design with five treatments and four replications for 42 days. The experimental treatments included control group (without Securigera securidaca seed powder) and four levels of Securigera securidaca seed. The results showed that the addition of Securigera securidaca seed powder to feed increased the carcass and thigh efficiency and reduced heart efficiency and RV/TV ratio. (P<0.05). In treatments containing 3 or 4 grams of Securigera securidaca, the total protein and nitric oxide levels of serum were significantly increased, and malondialdehyde, urea and heterophile to lymphocyte ratio decreased significantly compared to the control group (P<0.05). Also, the effect of this herbal drug on the expression of right ventricle genes of the heart showed that 3 and 4 g levels of Securigera securidaca in the diet significantly increased the expression of nitric oxide synthase and superoxide dismutase genes, and a significant reduction of endothelin-1 gene expression in this tissue (P<0.05). the results of this study showed that the using of 3 or 4 (g/kg) of medicinal plant Securigera securidaca seed is effective in reducing the pulmonary hypertension in broilers by improving the antioxidant status, immunity and biochemical parameters of blood.

کلیدواژه‌ها [English]

  • Pulmonary hypertension
  • Broiler chicken
  • Securigera securidaca
  • Heart failure
  • Gene expression

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