عنوان مقاله [English]
Recent studies show that medical vegetables such as Prosopis farcta have substances with antioxidant effect which decrease serum lipoprotein in animals fed with hyperlipidemic diet. The main purpose of this study was to investigate the effect of Prosopis farcta extract on serum lipid and liver enzymes in hyper-cholestrolemic rats. In this study, 20 vistar male rats with approximately 300-350 g-weight and 10-week age were taken from infertility center of Yazd. At first, the rats were fed with a base diet containing protein, fiber and fat for two weeks. Then they were randomly divided into four groups of five animals: Group 1, standard diet, Group 2, a diet containing cholesterol, Group 3, a diet containing standard diet with Prosopis extract and group 4, a cholestrolemic diet with Prosopis extract. All animals were fed for 13 weeks. Total cholestrole (TC), triglyceride (TG), Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), low density lipoprotein and high density lipoprotein were measured before the experiment, and 30 days and 90 days after feeding. The data were analyzed using one way Anova. The p-values below 0.05 (p
1-Abeywardena, M., and Runnie, I.(2002). Polyphenol-enriched extract of oil palm fronds (Elaeis guineensis) promotes vascular relaxation via endothelium dependent mechanism. Asia Pac. J. Clin. Nutr. 11(Suppl): S467–S472.
2-Afifi, F.(1993). Hypoglycemic effect of Prosopis farcta. International Journal of Pharmacology. 1:161-164.
3-Al-Qura, N.S.(2008). Taxonomical and pharmacological survey of therapeutic plants. Jordan .J .Nat. Prod. 1:10-26.
4-Asadollahi , K., Abbasi, N., Afshar, N., Alipour, M., and Asadollahi, P.(2010). Investigation of the effect of Prosopis farcta plant extract on rat aorta. J. Med. Plant .Res. 4(2):142-147.
5-Bill ,D.R., Gochenaur, K. (2006). Direct vasoactive and vasoprotective properties of anthocyanin rich extract. J. Applied. Physiol.100:1164-1170.
6-Boari ,C., Montanari, F.M., Galletti ,G.P., Rizzoli, D., Baldi, E., and Caudarella, R.(1981).Toxic occupational liver disease, Therapeutic effect of Silymarin. Minerva Med.72:2679-26 88.
7- Braunwald ,E.(2001). Heart disease; A text book of cardiovascular medicine, Saunders company, Sydney, Torento.
8-Braunwald ,E.(1997). Heartdisease, Saunders company, Philadelphia, Pensylvania.
9-Candan, F., and Sokmen , A. (2004) .Effect of Rhus coriaria L (Anacardiaceae) on lipid peroxidation and free radical scavenging activity. Phytother Res. 18(1):84-6.
10-Lankin ,V.Z.,Tikhaze , A., Kukharchulk, V.,and Belenkove, Y. (2003).Antioxidant decrease the intensification of LDL, in –vivo Proxidation, during therapy with statins. Molecular and Cellular Biochemistry. 249:126-140.
11-Luper, S.(1998). A review of plants used in the treatment of liver disease, Part 1. Altern. Med. Rev. 3:410-421.
12-Malik ,S.,Mann, S.,Gpta, D., and Guptar, R.K. (2013).Nutraceutical properties of Prosopis cineraria (L), Druce pods:A component of Panchkuta .J. pharmacognosy and phytochemistry. 2(2):66-73.
13-Moarreaf , A.R.(2004). Risk factor modification of coronary artey disease. Shiraz E-Medical Journal. 5:1-7.
14-Naderi , G.h., Asgary, S.,Gharipour, M.,Taher, M., and Khosravi , E.(2008). Antioxidant effect of Piper nigrum on hepatocyte membrane and LDL oxidation and non-enzymatic glycosylation of hemoglobin-number. Hakim Res J.10(4):11-6 (in farsi).
15-Ranjbar.Heydari, A.,Khayatzade, J., and keshtagar ,M.(2012).Study of root aqueous extract of Prosopis farcta effect on wound healing of diabetic adult male ratrs.Journal of Birjand University of Medical Sciences.19 (3):245-254.(in farsi).
16-Ross, R. (2002).The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 362 (6423):801-9.
17-Sharma , N., Garg ,V., and Paul, A.(2010). Antihyperglycemic, Antihyperlipidemic and Antioxidative potential of Prosopis cineraria bark. Indian. J. Clin. Biochem. 25(2):193-200.
18-Setorki, M., Rafieian, M., Heidarian, E., Ghatre, K. (2012).The Beneficial Effects of Vaccinium myrtilus L.Intake on Atherosclerosis Risk Factor in male new zealand rabbits.Journal of Zanjan University of Medical Sciences. 20(79):14-23.
19-Skottova, N., and Krecman, V.(1998).Dietry Silymarin improves removal of low density lipoprotein by perfused rat liver.Acta Univ.Palacki.Olomuc. Fac. Med. 141:39-40.
20-Taher ,M.,Ghannadi, A.,Karmiyan, R.(2007).Effect of volatile oil extracts of Anethum gravelons L and Apium gravelons L.seed on activity of liver enzymes in rat. J. Qazvin. Univ Med.2:8-12
21-Tunctan , B., Altug, S.,Uludag, O., and Abacioglu ,N. (2000).Effect of econazole on receptor-operated induced contraction in rat isolated aorta. Life Science.67(19): 2393-2401.
22-Walldius , G., and Jungner, I.(2004).Apolipoprotein B and Apolipoprotein A-I:Risk indicator of coronary heart disease and target for lipid modifying therapy. J. Intern Med.255(2):188-205.