عنوان مقاله [English]
Anaplasmosis is a tick-borne disease caused by the Anaplasma spp.. A. marginale is the most important species of vererinary in the family Anaplasmataceae. The disease is the most prevalent of bovine hemoparasite infections and is endemic in tropical, subtropical and certain temperate areas of the world. Invasion and multiplication of A. marginale in erythrocytes of cattle may result in anemia, weight loss, abortion, and sometimes death during acute infections. A. marginale is transmitted biologically by ticks and mechanically by blood-contaminated mouthparts of biting flies or fomites. Transplacental transmission of A. marginale may contribute to the epidemiology of bovine anaplasmosis in some regions. According to the recent studies in Iran, approximately a quarter of the examined cattle have been positive for A. marginale. In spite of the global importance, in Iran the disease is still often overlooked in diagnosis and treatment. There is little surveillance information about this disease in Iran due to poor recognition and report. This paper reviews the literature on anaplasmosis with special attention to the prevalence of the disease in Iran and the world to help veterinarians differentiate, diagnose, and treat this disease.
1. Aktas, M., K. Altay and N. Dumanli. 2011. Molecular detection and identification of Anaplasma and Ehrlichia species in cattle from Turkey. Ticks and tick-borne diseases 2(1):62-65.
2. Amorim, L.S., A. A. Wenceslau, F. S. Carvalho, P. L. S. Carneiro and G. R. Albuquerque. 2014. Bovine babesiosis and anaplasmosis complex: diagnosis and evaluation of the risk factors from Bahia, Brazil. Revista Brasileira de Parasitologia Veterinária 23(3):328-336.
3. Atif, F. A., M. S. Khan, H. J. Iqbal and T. Roheen. 2012. Prevalence of tick-borne diseases in Punjab (Pakistan) and hematological profile of Anaplasma marginale infection in indigenous and crossbred cattle. Pakistan Journal of Science 64:11–15.
4. Atif, F. A., M. S. Khan, F. Muhammad, and B. Ahmad. 2013. Seroepidemiological study of Anaplasma marginale among cattle. Journal of Animal and Plant Sciences 23:740–744.
5. Atif, F.A., 2015. Anaplasma marginale and Anaplasma phagocytophilum: Rickettsiales pathogens of veterinary and public health significance. Parasitology research 114(11): 3941-3957.
6. Aubry, P. and D. W. Geale. 2011. A review of bovine anaplasmosis. Transboundary and emerging diseases 58:1–30.
7. Awad, H., S. Antunes, R. C. Galindo, V. E. do Rosario, J. De la Fuente, A. Domingos and El Hussein, A. M. 2011. Prevalence and genetic diversity of Babesia and Anaplasma species in cattle in Sudan. Veterinary parasitology 181(2):146-152.
8. Belkahia, H., M. B. Said, A. Alberti, K. Abdi, Z. Issaoui, D. Hattab, M. Gharbi and L. Messadi. 2015. First molecular survey and novel genetic variants’ identification of Anaplasma marginale, A. centrale and A. bovis in cattle from Tunisia. Infection Genetics and Evolution 34:361-371.
9. Brown, W.C. 2008. Unraveling the immune regulatory mechanisms imposed by Anaplasma.Veterinary Journal 175(1):1-10.
10. Canever, M.F., L. L.Vieira, C. Reck, L Richter and L.C. Miletti. 2014. First evaluation of an outbreak of bovine babesiosis and anaplasmosis in Southern Brazil using multiplex PCR. The Korean journal of parasitology 52(5):507.
11. Carelli, G., N. Decaro, A. Lorusso, G. Elia, E, Lorusso, V, Mari, L. Ceci and C. Buonavoglia. 2007. Detection and quantification of Anaplasma marginale DNA in blood samples of cattle by real-time PCR. Veterinary Microbiology 124:107-104.
12. Costa, V. M. D. M., M. F. B. Ribeiro, A. L. L. Duarte, J. M. Mangueira, A. F. A. Pessoa, S. S. Azevedo and M. B. Labruna. 2013. Seroprevalence and risk factors for cattle anaplasmosis, babesiosis, and trypanosomiasis in a Brazilian semiarid region. Revista Brasileira de Parasitologia Veterinária, 22(2): 207-213
13. da Silva, J. B. and A. H. da Fonseca. 2013. Analysis of the risk factors related to the immune humoral anti-Anaplasma marginale in dairy cattle. Semina: Ciencias Agrarias, 34(2): 777-784
14. da Silva, J. B., G. N. de Santana Castro and A. H. Fonseca. 2014. Longitudinal study of risk factors for anaplasmosis and transplacental transmission in herd cattle. Semina: Ciências Agrárias, 35(4Supl): 2491-2500
15. da Silva, J. B., and A. H. da Fonseca. 2014. Risk factors for anaplasmosis in dairy cows during the peripartum. Tropical animal health and production, 46(2): 461-465
16. da Silva, A.S., L.S. Lopes, J.D.S. Diaz, A.A. Tonin, L. M. Stefani and D.N. Araujo. 2013. Lice outbreak in buffaloes: evidence of Anaplasma marginale transmission by sucking lice Haematopinus tuberculatus. The Journal of parasitology 99:546–547.
17. de la Fuente, J., R. A. Van Den Bussche, T. Prado and K. M. Kocan 2003. Anaplasma marginale major surface protein 1 genotypes evolved under positive selection pressure but are not a marker for geographic isolates. Journal of Clinical Microbiology 41:1609-1616.
18. Dreher, U.M., J. de la Fuente, R. Hofmann-Lehmann, M. L. Meli, N. Pusterla, N., K. M. Kocan, Z. Woldehiwet, U. Braun, G. Regula, K. D. C. Staerk and H. Lutz. 2005. Serologic cross reactivity between Anaplasma marginale and Anaplasma phagocytophilum. Clinical and Diagnostic Laboratory Immunology 12:1177–1183.
19. Dumler, J. S., A. F. Barbet, C. P. J. Bekker, G. A. Dasch, G. H. Palmer, S. C. Ray, Y. Rikihisa and F. R. Rurangirwa. 2001. Reorganization of the genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and "HGE agent" as subjective synonyms of Ehrlichia phagocytophila. The International Journal of Systematic and Evolutionary Microbiology 51:2145-2165.
20. Eriks, I. S., G. H. Palmer, T. C. McGuire, D. R. Allred and A. F. Barbet. 1989. Detection and quantitation of Anaplasma marginale in carrier cattle by using a nucleic acid probe. Journal of Clinical Microbiology 27(2):279-84.
21. Georges, K., G.R. Loria, S. Riili, A. Greco, S. Caracappa, F. Jongejan and O. Sparagano. 2001. Detection of haemoparasites in cattle by reverse line blot hybridisation with a note on the distribution of ticks in Sicily. Veterinary Parasitology 99(4):273-86.
22. Hairgrove, T., M. E. Schroeder, C. M. Budke, S. Rodgers, C. Chung, M. W. Ueti and M. A. Bounpheng. 2015. Molecular and serological in-herd prevalence of Anaplasma marginale infection in Texas cattle. Preventive veterinary medicine 119(1):1-9.
23. Hairgrove, T.B., T. M. Craig, C. M. Budke, S. J. Rodgers and R. J. Gill. 2014. Seroprevalence of Anaplasma marginale in Texas cattle. Preventive veterinary medicine 116(1):188-192.
24. Hamou, S.A., T. Rahali, H. Sahibi, D. Belghyti, B. Losson, W. Goff and A. Rhalem. 2012. Molecular and serological prevalence of Anaplasma marginale in cattle of North Central Morocco. Research in veterinary science 93(3):1318-1323.
25. Kivaria, F.M., A. M. Kapaga, G. K. Mbassa, P. F. Mtui and R. J. Wani. 2012. Epidemiological perspectives of ticks and tick-borne diseases in South Sudan: Cross-sectional survey results. Onderstepoort Journal of Veterinary Research 79(1):1-10.
26. Kocan, K. M., J. de la Fuente, A. A. Guglielmone and R. D. Melendez. 2003. Antigens and Alternatives for Control of Anaplasma marginale Infection in Cattle. Clinical Microbiology Reviews 16(4):698-712.
27. Kocan, K. M., E. F. Blouin and A. F. Barbet. 2000. Anaplasmosis control: past, present and future. Annals of the New York Academy of Sciences 916:501-509.
28. Kocan, K.M., J. de la Fuente, E.F. Blouin, J.F. Coetzee and S. A. Ewing. 2010. The natural history of Anaplasma marginale. Veterinary parasitology 167:95–107.
29. Kocan, K.M., J. de la Fuente, D.L. Step and E.F. Blouin. 2010. Current challenges of the management and epidemiology of bovine anaplasmosis. Bovine Practice, 44:93–102.
30. Kubelova, M., J. Mazancova and P. Siroky. 2012. Theileria, Babesia, and Anaplasma detected by PCR in ruminant herds at Bié Province, Angola. Parasite 19(4):417.
31. Lew, A. F., K. R. Gale, C. M. Minchin, V. Shkap and V. de Waal. 2003. Phylogenetic analysis of the erythrocytic Anaplasma species based on 16S rDNA and GroEl (HSP60) sequences of A. marginale, A. centrale, and A. ovis and the specific detection of A. centrale vaccine strain. Veterinary Microbiology 20:145-160.
32. Molad, T., M. L. Mazuz, L. Fleiderovitz, L. Fish, I. Savitsky, Y. Krigel, B. Leibovitz, J. Molloy, F. Jongejan and V. Shkap. 2006. Molecular and serological detection of A. centrale and A. marginale infected cattle grazing within an endemic area. Veterinary Microbiology 113(1-2):55-62.
33. Moumouni, P.F.A., G. O. Aboge, M. A. Terkawi, T. Masatani, S. Cao, K. Kamyingkird, C. Jirapattharasate, M. Zhou, G. Wang, M. Liu and A. Iguchi. 2015. Molecular detection and characterization of Babesia bovis, Babesia bigemina, Theileria species and Anaplasma marginale isolated from cattle in Kenya. Parasites and vectors 8(1):1.
34. Mutshembele, A.M., A. Cabezas-Cruz, M. S. Mtshali, O. M. Thekisoe, R. C. Galindo and J. de la Fuente. 2014. Epidemiology and evolution of the genetic variability of Anaplasma marginale in South Africa. Ticks and tick-borne diseases 5(6):624-631.
35. Nair, A.S., R. Ravindran, B. Lakshmanan, C. Sreekumar, S. S. Kumar, R. Raju, P. V. Tresamol, M. B. Vimalkumar and M. R. Saseendranath. 2013. Bovine carriers of Anaplasma marginale and Anaplasma bovis in South India. Tropical biomedicine 30(1):105-112.
36. Njiiri, N. E., N. E. Collins, H. C. Steyn, M. Troskie, I. Vorster, S. M. Thumbi, K. P. Sibeko, A. Jennings, I. C. van Wyk, M. Mbole-Kariuki and H. Kiara. 2015. The epidemiology of tick-borne haemoparasites as determined by the reverse line blot hybridization assay in an intensively studied cohort of calves in western Kenya. Veterinary parasitology 210(1):69-76.
37. Noaman, V., S. Arabzadeh and B. Kachooei. 2002. A study on Anaplasmosis in cattle of Falavarjan city, Isfahan province (1995-200). Pajouhesh – Va- Sazandegi 51:10-12.
38. Noaman, V., P. Shayan, and N. Amininia. 2009. Molecular diagnostic of Anaplasma marginale in carrier cattle. Iranian Journal of Parasitology 4(1): 31-38.
39. Noaman, V., and P. Shayan. 2009. Molecular detection of Anaplasma phagocytophilum in carrier cattle of Iran - first documented report. Iranian Journal of Microbiology 1(2): 37-42.
40. Noaman, V., and P. Shayan. 2009. Comparison of Microscopic methods and PCR-RFLP for detection of Anaplasma marginale in carrier cattle. Iranian Journal of Microbiology 2(2): 89-94.
41. Noaman, V., P. Shayan and A. H. Shahmoradi. 2010. Detection of Anaplasma ovis based on 16S rRNA gene by PCR-RFLP in sheep from central part of Iran. Journal of Veterinary Medicine and Laboratory 1(1): 27-37.
42. Noaman, V., and P. Shayan. 2010. Molecular detection of Anaplasma bovis in cattle from central part of Iran. Veterinary Research Forum 1(2): 117-122.
43. Noaman, V., and P. Shayan. 2010. A new PCR-RFLP method for detection of Anaplasma marginale based on 16S rRNA. Veterinary Research Communications 34(1): 43-50.
44. Noaman, V. 2012. Identification of hard ticks collected from sheep naturally infected with Anaplasma ovis in Isfahan province, central Iran. Comparative Clinical Pathology 21, 367–369.
45. Noaman, V. 2013. Report of Anaplasma centrale (Amori strain) in cattle in Iran. Veterinary Journal (Pajouhesh and Sazandegi) 98: 26-29.
46. Noaman, V. 2013. Discrimination between Anaplasma marginale and Anaplasma ovis by PCR-RFLP. World Applied Sciences Journal 21(2): 190-195.
47. Noaman, V., A. R. Hatami, S. Esmaeilkhanian, A. H. Shahmoradi and M. R. Heidari. 2015. Molecular detection of Anaplasma species in cattle and sheep of Iran. Final report of national research project. Agricultural Research, Education and Extension Organization (AREEO). Tehran, Iran.
48. Noaman, V., and D. Bastani. 2016. Molecular study on infection rates of Anaplasma ovis and Anaplasma marginale in sheep and cattle in West-Azerbaijan province, Iran. Veterinary Research Forum 7 (2): 163 – 167.
49. Noaman, V., A. Nabinejad, A. Shahmoradi and S. Esmaeilkhanian. 2016. Molecular detection of bovine leukocytic Anaplasma species in Isfahan, Iran. Research in Molecular Medicine 4 (2): 47-51.
50. Ministry of Jihad-e-Agriculture. 2015. Deputy for animal production affairs. Available online at.http://dla.agri-jahad.ir/Portal/Home/
51. Ochirkhuu, N., S. Konnai, C. N. Mingala, T. Okagawa, M. Villanueva, F. M. I. R. Pilapil, S. Murata and K. Ohashi. 2015. Molecular epidemiological survey and genetic analysis of vector-borne infections of cattle in Luzon Island, the Philippines. Veterinary parasitology 212(3):161-167.
52. OIE. 2012. World Organization for Animal Health. OIE terrestrial manual, Section 2.4. Bovinae, In: Chapter 2.4.1. Bovine anaplasmosis; Paris, France, 589–600.
53. Rahman, A. S. M. S., S. M. M. R. Sumon, M. A. H. N. A. Khan and M. T. Islam. 2015. Current status of subclinical form of babesiosis and anaplasmosis in cattle at Rangpur district in Bangladesh. Progressive Agriculture, 26(1): 51-59.
54. Rikihisa, Y., 2011. Mechanisms of obligatory intracellular infection with Anaplasma phagocytophilum. Clinical microbiology reviews 24:469–489.
55. Sajid, M. S., R. M. Siddique, S. A. Khan, Z. Iqbal, and M. N. Khan. 2014. Prevalence and Risk Factors of Anaplasmosis in Cattle and Buffalo Populations of District Khanewal, Punjab, Pakistan. Global Veterinaria 12 (1): 146-153.
56. Sharma, A., L. D. Singla, P. Kaur and M. S. Bal. 2015. PCR and ELISA vis-a-vis Microscopy for Detection of Bovine Anaplasmosis: A Study on Associated Risk of an Upcoming Problem in North India. The Scientific World Journal 2015.
57. Sharma, A., L. D. Singla, A. Tuli, P. Kaur and M. S. Bal. 2015. Detection and assessment of risk factors associated with natural concurrent infection of Trypanosoma evansi and Anaplasma marginale in dairy animals by duplex PCR in eastern Punjab. Tropical animal health and production 47(1):251-257.
58. Shebish, E., R. Vemulapalli and C. Oseto. 2012. Prevalence and molecular detection of Anaplasma marginale, Babesia bovis and Babesia bigemina in cattle from Puntarenas Province, Costa Rica. Veterinary parasitology 188(1):164-167.
59. Singh, H., M. Haque, N. K. Singh and S. S. Rath. 2012. Molecular detection of Anaplasma marginale infection in carrier cattle. Ticks and tick-borne diseases 3(1):55-58.
60. Singh, N.K., H. Singh, M. Haque and S. S. Rath. 2012. Prevalence of parasitic infections in cattle of Ludhiana district, Punjab. Journal of parasitic diseases 36(2):256-259.
61. The Merck Veterinary Manual. 2014. Available online at.http://www.merckvetmanual.com/mvm/index.jsp. Accessed 25 January 2015.
62. Urdaz-Rodriguez, J. H., G. T. Fosgate, A. R. Alleman, D. O. Rae, G. A. Donovan and P. Melendez. 2009. Seroprevalence estimation and management factors associated with high herd seropositivity for Anaplasma marginale in commercial dairy farms of Puerto Rico. Tropical animal health and production, 41(7), 1439-1448.
63. Ybanez, A.P., T. Sivakumar, B. Battsetseg, B. Battur, K. Altangerel, K. Matsumoto, N. Yokoyama and H. Inokuma. 2013. Specific molecular detection and characterization of Anaplasma marginale in Mongolian Cattle. Journal of Veterinary Medical Science 75(4):399-406.
64. Ybanez, A.P., T. Sivakumar, R. H. D. Ybanez, J. C. Ratilla, Z. O. Perez, S. R. Gabotero, H. Hakimi, S. I. Kawazu, K. Matsumoto, N. Yokoyama and H. Inokuma. 2013. First molecular characterization of Anaplasma marginale in cattle and Rhipicephalus (Boophilus) microplus ticks in Cebu, Philippines. Journal of Veterinary Medical Science 75(1):27-36.
65. Ybanez, A.P., R. H. D. Ybanez, F. G. Claveria, M. J. CRUZ-FLORES, X. Xuenan, N. Yokoyama and H. Inokuma. 2014. High genetic diversity of Anaplasma marginale detected from Philippine Cattle. The Journal of Veterinary Medical Science 76(7):1009.
66. Zhou, M., S. Cao, F. Sevinc, M. Sevinc, O. Ceylan, P. F. A. Moumouni, C. Jirapattharasate, M. Liu, G. Wang, A. Iguchi and P. Vudriko. 2016. Molecular detection and genetic identification of Babesia bigemina, Theileria annulata, Theileria orientalis and Anaplasma marginale in Turkey. Ticks and tick-borne diseases 7(1):126-134.