عنوان مقاله [English]
Infectious bronchitis is one of the widespread and highly infectious viral disease of poultry. In this study to gain insights into transcriptional regulation of infection bronchitis, at the first high expression genes in infection bronchtis in four different conditions were identified by RNA-Seq data analysis. In this study to gain insights into transcriptional regulation of infection bronchitis, at the first high expression genes in infection bronchitis were identified by RNA-Seq data analysis in four different conditions including comparison of the spleen chickens with bronchitis versus healthy with low serum concentration of mannose-binding lectin at the age of one and three weeks, comparison of the spleen chickens with bronchitis versus healthy with high serum concentration of mannose-binding lectin at the age of one and three weeks. Then promoter regions of these genes were extracted to identify candidate transcription factors involved in this mechanisms. Promoter analysis by using Genomatix software lead to identify of 61 novel transcription factors candidates activating in infection bronchitis. In this study in order to visualization of regulatory networks containing transcription factors and that regulate the genes, the were used Cytoscape software. According to the results, 61 new candidates transcription factor introduced in this study has good potential for more inestigation in the laboratory level and can provide new information to better understanding of regulatory networks in infectious bronchitis in poultry.
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