مروری بر استفاده واکسن دز کاهیده بروسلا ملی تنسیس سویه Rev.1 در دامهای بالغ

نوع مقاله: مقاله مروری

نویسندگان

1 موسسه تحقیقات واکسن و سرم سازی رازی ، تضمین کیفیت، مسئول فنی واکسن‌های موسسه رازی، سازمان تحقیقات، آموزش و ترویج کشاورزی، تهران، ایران

2 استاد بازنشسته موسسه تحقیقات واکسن و سرم سازی رازی، سازمان تحقیقات، آموزش و ترویج کشاورزی، تهران، ایران

چکیده

بروسلوز یکی از مهم‌ترین زئونوزها بوده که بوسیله گونه‌های مختلف بروسلا به ویژه بروسلا ملی‌تنسیس ایجاد می‌گردد. آسان‌ترین راه کنترل بیماری واکسیناسیون تمام نشخوارکنندگان کوچک می‌باشد. واکسن  بروسلا ملی‌تنسیس سویه  Rev.1 به عنوان بهترین واکسن موجود و مورد استفاده برای پیشگیری بروسلوز است. روش توصیه شده برای کنترل بیماری واکسیناسیون بره‌ها و بزغاله‌ها با یک دز استاندارد و جایگزینی با دام‌های بالغ بود که در بعضی از کشورهای توسعه یافته و اکثر کشورهای در حال توسعه کاملا موفقیت‌آمیز نبوده است. واکسیناسیون دام‌های بالغ آبستن با دز کامل واکسن Rev.1 به ویژه در ماه‌های دوم و سوم باعث سقط جنین اکثر دام‌های آبستن می‌شود. استفاده وسیع از واکسن دز کاهیده بروسلا ملی‌تنسیس سویه Rev.1 به عنوان روش مطلوب و تکمیلی برای پیش‌گیری بروسلوز در نشخوارکنندگان کوچک پیشنهاد شده و نتایج آزمایشگاهی و میدانی بیانگر کاهش قابل توجه سقط جنین در میش‌های آبستن و میزان بیماری در انسان است. هدف از  این مطالعه، مروری بر  نتایج به دست آمده از مصرف دز کاهیده واکسن Rev.1 در دام‌های بالغ بوده که برای رفع مشکل سقط جنین و کنترل بروسلوز استفاده شده است.

کلیدواژه‌ها


عنوان مقاله [English]

A review of the use of Reduced-Dose Vaccine of B. melitensis Rev1 strain in adult sheep

نویسندگان [English]

  • Mohammad Ebrahimi 1
  • Esmail Zowghi 2
1 Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organisation (AREEO), Tehran, Iran.
2 Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organisation (AREEO), Tehran, Iran.
چکیده [English]

A review of the use of reduced dose vaccine of B.melitensis Rev1 strain in adult sheep

Brucellosis is one of the most widespread zoonoses in the world caused by several species of the genus Brucella. The only feasible alternative to control B. melitensis infection in small ruminants is whole-flock vaccination under an extensive management. The live Brucella melitensis Rev 1 strain is considered as the best vaccine available for prevention of animal brucellosis. The classically recommended exclusive vaccination of young replacement animals has failed to control brucellosis in some developed countries and is frequently inapplicable in the developing countries. The vaccination of pregnant animals with full standard doses of Rev 1 administered subcutaneously is followed by abortion in most vaccinated animals. Reducing the dose of vaccine has been suggested as a method of avoiding this problem and, accordingly, a reduced-dose vaccination strategy has been widely used and reported as a safe and effective method of controlling small ruminant brucellosis. Moreover, we reviewed field and experimental results supporting the reduction of abortion in pregnant animals and fewer reports of human brucellosis as results of this strategy. The aim of this study was to review the results obtained from the use of reduced doses of Rev.1 vaccine in adult animals to overcome the problem of abortion and control the disease.

کلیدواژه‌ها [English]

  • B. melitensis
  • Rev.1 vaccine
  • reduced dose
  • Adult sheep

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