عنوان مقاله [English]
Stereotactic brain surgery is often used in different types of animal research and basic studies. One of its most application is to target specific sites of the brain for direct injecting of pharmacological agents which otherwise may not be able to cross the blood-brain barrier. Because of that the present study was designed to examine the effect of food deprivation (FD) before the surgery on the survival rate in 4 experimental groups of broiler cockerels. Chickens were reared with continuous lighting until 3 weeks age. At three weeks of age, a guide cannula was stereotaxically implanted into the right lateral ventricle of each bird. In group 1, birds had free access to feed during the experimental period. In groups 2, 3 and 4; chickens had 3, 6 and 12 hours of FD before the surgery, respectively. The Data were analyzed by two-way ANOVA in SPSS software. Our results showed that FD can decrease the incidence of mortality in broiler cockerels after stereotactic surgery (P<0.05). The best time of FD was 6 hours prior to surgery, and an increase of FD from six to twelve showed the same effect on the bird's survival rate. Based on the results of the current study, off–feed 6 hours prior to the stereotactic brain surgery is suggested in broiler chickens.
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